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KMID : 1035220150070010009
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Korean Journal of Neuromuscular Disorders
2015 Volume.7 No. 1 p.9 ~ p.21
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Cognitive and Behavioral Impairment in Amyotrophic Lateral Sclerosis
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Oh Seong-Il
Kim Seung-Hyun
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Abstract
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Cognitive and behavioral impairment in amyotrophic lateral sclerosis (ALS) is now well recognized that there is clinical, pathological and genetic overlap between ALS and frontotemporal dementia (FTD). Although the cognitive and behavioral status of most patients is not yet fully recognized, roughly up to half of patients with ALS develop cognitive and behavioral impairments and a smaller subgroup of ALS patients, who impaired more severely in cognitive function and behavior, meet the criteria for the FTD (ALS-FTD). Deficits are characterized by executive impairments, extending to changes in language and social cognition, then implying a clinical spectrum linking ALS and FTD. Understanding of cognitive and behavioral impairment in ALS will improve clinical management for patients and their carers and provide valuable clues to encompass the heterogeneity of cognitive and behavioral impairments in ALS and other neurodegenerative diseases.
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KEYWORD
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Amyotrophic lateral sclerosis, Frontotemporal dementia, Cognition, Behavior
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